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KMID : 0043320100330040499
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Archives of Pharmacal Research
2010 Volume.33 No. 4 p.499 ~ p.502
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Two New Hetero-Spirocyclic γ -Lactam Derivatives from Marine Sediment-derived Fungus Aspergillus sydowi D2-6
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Gu Qian-Qun
Ren Hong
Liu Rui
Chen Li
Zhu Tianjiao
Zhu Wei Ming
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Abstract
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Two new hetero-spirocyclic γ-lactams, azaspirofurans A (1) and B (2), had been isolated from a marine sediment-derived fungus Aspergillus sydowi D2-6. Their structures were determined by the chemical evidence and spectral analyses. Compound 1 exhibited cytotoxicity against A549 cell line with the IC50 value of 10 μM by MTT method.
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KEYWORD
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Marine sediment-derived, Aspergillus sydowi D2-6, Azaspirofurans A, Cytotoxicity
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